Protein Purification
MilliporeSigma™ Calbiochem™ T0901317
A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20nM for LXRα
MilliporeSigma™ Calbiochem™ CFTR Activator, Cact-A1
A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50
MilliporeSigma™ Calbiochem™ 5-Lipoxygenase Inhibitor, MK591
MK591; MK0591; 5-LOX inhibitor, 5- Lipoxygenase inhibitor, FLAP
MilliporeSigma™ Calbiochem™ CRAC Channel Inhibitor, BTP2
The CRAC Channel Inhibitor, BTP2, also referenced under CAS 223499-30-7, controls the biological activity of CRAC Channel. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ PD 153035
An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; K
MilliporeSigma™ Calbiochem™ β-Catenin/Tcf Inhibitor VI, ICG-001
A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25μM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE c
MilliporeSigma™ Calbiochem™ JAK3/GSK-3β/PKCα Inhibitor
The JAK3/GSK-3β/PKCα Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3β/PKCα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Olomoucine
A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
MilliporeSigma™ Calbiochem™ Pravastatin, Sodium Salt
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ≈1 nM).
MilliporeSigma™ Calbiochem™ Ursolic Acid
A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities.
MilliporeSigma™ Calbiochem™ InSolution™ Y-27632 in DMSO
InSolution™ Y-27632 is a 10mm solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140nM for p160ROCK).
MilliporeSigma™ Calbiochem™ Bortezomib
Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.
MilliporeSigma™ Calbiochem™ InSolution™ MEK1/2 Inhibitor III, PD0325901
The InSolution™ MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ AICA-Riboside
AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.
MilliporeSigma™ Calbiochem™ Caspase-6 Substrate III, Fluorogenic
A fluorogenic substrate for caspase-6 (Mch2).